RNA Binding Protein LIN28B: a prime time player shaping neuroblastoma aggression and metastasis
نویسندگان
چکیده
منابع مشابه
The RNA-binding protein LIN28B regulates developmental timing in the mammalian cochlea.
Proper tissue development requires strict coordination of proliferation, growth, and differentiation. Strict coordination is particularly important for the auditory sensory epithelium, where deviations from the normal spatial and temporal pattern of auditory progenitor cell (prosensory cell) proliferation and differentiation result in abnormal cellular organization and, thus, auditory dysfuncti...
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LIN28B is a homologue of LIN28 that induces pluripotency when expressed in conjunction with OCT4, SOX2, and KLF4 in somatic fibroblasts. LIN28B represses biogenesis of let-7 microRNAs and is implicated in both development and tumorigenesis. Recently, we have determined that LIN28B overexpression occurs in colon tumors. We conducted a comprehensive analysis of LIN28B protein expression in human ...
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ژورنال
عنوان ژورنال: Oncoscience
سال: 2020
ISSN: 2331-4737
DOI: 10.18632/oncoscience.512